10 Postdoctoral Fellowship at University of Nottingham, England

This is an exciting MRC-JPIAMR funded project, titled FightAMR: Novel global One Health surveillance approach to fight AMR using Artificial Intelligence and big data mining. The research fellow will take a leading role in an EU-Africa research project, collaborating with Research Organisations, Academia, and Industry in South Africa, Switzerland, France, Italy and the UK. The aim of this research is to understand the emergence, spread and transmission of drug-resistant pathogens under the One Health concept, and to use this knowledge to develop an innovative AI-powered surveillance solution. Covering all the interconnected systems humans, animals, environment and food across EU and Africa. To this aim, we will use artificial intelligence, bioinformatics, next generation sequencing and microbiology. The successful candidate will work closely with an interdisciplinary team of academics at University of Nottingham. The role will include data analysis via machine learning, bioinformatics, sequencing and microbiology.

We are looking to appoint an enthusiastic Research Fellow with interests and experience in developing Transmission Electron Microscopy (TEM) based correlative approaches for native state / cryogenic materials imaging and analyses. 

The role will be based in the Nanoscale and Microscale Research Centre (nmRC) at the University of Nottingham. The Research Fellow must have good knowledge and practical skills of the imaging of biological/organic materials at the micro/nano-scale and an understanding of current limitations of these techniques.  In particular, the Research Fellow should possess skills in preparing and preserving biological/organic samples for imaging and analysis. They will use these capabilities to underpin method development and the creation of innovative solutions to the characterisation challenges presented by University of Nottingham researchers and external users, helping establish the nmRC as a leader this field.

The role will lead on TEM based approaches to soft matter, organic or hydrated materials analysis, working both within and at the interface to the cryogenic analytical and transfer (CAT) microscopy suite at the nmRC to establish and optimise novel or correlative workflows: https://www.nottingham.ac.uk/nmRC/Tours/nmCS-Tours.aspx 

Applicants must have a good first degree in a life science or related discipline, a PhD submitted (imminent submission acceptable) or awarded in an area related to life sciences/pharmacy/biomedical engineering and experience of preparing biological (or related) samples for imaging and analysis. Excellent communication skills including the ability to communicate complex information with clarity and write to a publishable standard are required.

The nmRC is a world leading analytical facility at the University of Nottingham. It provides state-of-the-art instrumentation and expertise in nanoscale characterization, specialised sample preparation, and micro/nano-structure fabrication, for the benefit of all University of Nottingham researchers, external academic collaborators and industrial partners. The nmRC enables and enhances cross-faculty collaborations and fosters external collaborations with internationally leading institutions; provides a first-class environment for training & career development; and exploits opportunities for knowledge transfer and collaboration with industry. More information can be found on the nmRC website (www.nottingham.ac.uk/nmrc).

This is a fixed-term post available for 36 months. Hours of work are full-time (36.25 hours); however, applications are also welcome from candidates wishing to work part-time (minimum 30 hours per week). Please specify in your application if you wish to work part time and the number of preferred hours. Arrangements for job share may be considered.

Applications are invited for the role of Research Associate/Fellow in the School of Medicine, University of Nottingham, to join the group of Dr Peter Aldiss whose research focusses on the hormonal and genetic regulation of obesity, addiction and the gut-liver-brain axis. You will be working within the GI and Liver theme of the NIHR Biomedical Research Centre and the Biodiscovery Institute (https://www.nottingham.ac.uk/research/research-areas/biodiscovery-institute/biodiscovery-institute.aspx), with access to a range of state-of-the-art facilities.

You will have the exciting opportunity to deliver a human volunteer pilot-study in healthy participants involving intake of sugar and alcohol, neuroimaging, collection of biological samples and subsequent analysis using molecular biology techniques.  You will be able to plan and conduct your own work independently, whilst also being able to build relationships and collaborate with others. A PhD (or near to completion) in human metabolic physiology, nutrition, imaging, or relevant area is essential. 

Applications are invited for the above post based in the Department of Mechanical, Materials and Manufacturing Engineering in the Faculty of Engineering at University Park, Nottingham.  This post will complement and strengthen research related activities within The Rolls-Royce University Technology Centre (UTC) in Manufacturing and On-Wing Technology at the University of Nottingham. The research of the UTC has been highly ranked in the field of manufacturing related areas and is carrying out the leading technologies in these fields. 

This post will focus on the study of advanced machining technologies and surface integrity inspection methods for difficult-to-machine materials (e.g. superalloys and biomedical materials). It is supposed to study the material machining performance through different techniques in detail. Another objective is to study the cutting tool performance and their design mechanism. 

The successful candidate will be expected to join the Rolls-Royce UTC in Manufacturing and On-Wing Technology and contribute to high quality research. Candidates should have good independent research capabilities, publications in high-impact academic journal, ability to work with industrial/academic partners, and experience of carrying out successful projects.

The successful candidate will join a multidisciplinary project funded by Human Frontiers Science Program Grant. The overall aim of the post will be to develop an in vitro model of plant roots using a self-assembled biomaterial based on the co-assembly of peptides with biomolecules such as proteins. The material will enable the incorporation of relevant cells and biological signals and be compatible with biofabrication techniques. The successful candidate will be responsible for optimizing the self-assembly process, characterization of the materials, fabrication of the scaffolds, and their biological validation.

This work will be based within the School of Pharmacy and the Biodiscovery Institute (www.nottingham.ac.uk/research/research-areas/biodiscovery-institute/biodiscovery-institute.aspx) and led by Prof. Alvaro Mata (School of Pharmacy and Department of Chemical Engineering) and Prof. Gabriel Castrillo (Plant and Crop Sciences) at the University of Nottingham. The candidate will be required to undertake research and day-day management of this research project, requiring a high degree of competence, problem-solving, critical thinking, and collaborative work.

Applicants must be highly motivated and self-driven, with a PhD (or equivalent) in Materials Science, Bioengineering, Biology, or related disciplines. It is desirable for the successful candidate to have considerable experience in one or more of the following: Self-assembling peptides; Polymer and peptide cross-linking; Cell and tissue culture; Hydrogels; Different microscopy techniques; Immunohistochemistry; Supramolecular chemistry.

The iBreed programme is a collaborative project between research teams led by Prof. Ramiro Alberio at the University of Nottingham and Dr. Tom Burdon and Prof. Bruce Whitelaw at University of Edinburgh (Roslin Institute). The team’s expertise in genetic engineering, stem cell and developmental biology will be applied to characterising bovine gametogenesis in vivo and directing differentiation in vitro. The project will focus on using state-of-the art genomic and epigenetic tools, gene editing and stem cell technologies available in the collaborating laboratories, to generate bovine gametes in vitro. 

Successful applicants will have a strong scientific background in areas such as developmental/stem cell biology, organ culture, and/or gene editing/manipulation and will be expected to work collaboratively within and between the two teams. Applicants must be highly motivated and self-driven, and able to work independently and collaboratively. Applicants will have a PhD in cell/developmental biology or related area of biological science (PhD students about to submit their thesis in a relevant area of stem cell biology will be considered). A track record of publishing research is essential. Experience in bioinformatics and cellular differentiation is relevant for the project. 

The iBreed programme is a collaborative project between research teams led by Prof. Ramiro Alberio at the University of Nottingham and Dr. Tom Burdon and Prof. Bruce Whitelaw at University of Edinburgh (Roslin Institute). The team’s expertise in genetic engineering, stem cell and developmental biology will be applied to characterising bovine gametogenesis in vivo and directing differentiation in vitro. The project will focus on using state-of-the art genomic and epigenetic tools, gene editing and stem cell technologies available in the collaborating laboratories, to generate bovine gametes in vitro. 

Successful applicants will have a strong scientific background in areas such as developmental/stem cell biology, organ culture, and/or gene editing/manipulation and will be expected to work collaboratively within and between the two teams. Applicants must be highly motivated and self-driven, and able to work independently and collaboratively. Applicants will have a PhD in cell/developmental biology or related area of biological science (PhD students about to submit their thesis in a relevant area of stem cell biology will be considered). A track record of publishing research is essential. Experience in bioinformatics and cellular differentiation is relevant for the project.