05 Postdoctoral Fellowship Position at European Molecular Biology Laboratory (EMBL), Germany

The project will involve the design of a pipeline to quantify single-cell gene expression data in 3D image datasets (stitching, registration, and quantification), followed by data analysis to reconstruct and quantify follicles during development. Tissue architecture will then be characterized in 3D by combining representation learning strategies (to extract key features of tissue microenvironments in an unbiased manner) and classical algorithms for multiscale morphology description. The joint consideration of learned features and visual descriptors will help construct an interpretable and robust characterization of tissue microenvironments, which will then allow identifying and quantifying architectural changes.

The Savitski group at EMBL Heidelberg is seeking a postdoc with a proteomics/biochemistry background to work on applying functional proteomics methods to study the mechanism behind protein aging in vivo. In particular, the candidate will work on combining Thermal Proteome Profiling (TPP), Solubility Proteome Profiling (SPP), protein turnover analysis and extensive post-translational modification analysis to understand the mechanisms of protein aging.

EMBL is seeking a postdoctoral scientist to join Dr. Jan Korbel’s group in the Genome Biology Unit. The Korbel group combines computational and experimental approaches, including in single cells, to unravel determinants and consequences of germline and somatic genetic variation. We are looking for young scientists with a largely computational, and possibly hybrid (experimental and computational) background, to work on spatially-resolved omics analysis relating to the 3D topological distribution of transcriptomes and their underlying mutational makeup in three different types of cancer – colorectal cancer, breast cancer and pancreatic cancer. This post will be funded by the SATURN3 consortium, a German Decade against Cancer flagship project in which the Korbel group plays a leading role. The post holder will join an interdisciplinary team that uses and develops cutting edge methods in spatial and time-resolved genomics, and will be responsible for the computational analyses of datasets in an inspiring lab atmosphere as well as an environment in which unique technologies are being developed. Prior experience in single-cell, spatial, and/or imaging data analysis will be a huge plus for candidate post holders

The Müller group is looking to recruit a highly motivated and cross-disciplinary postdoctoral researcher to pursue structure-function analyses of RNA polymerase I and RNA polymerase III transcription complexes. The Müller group (https://www.embl.org/groups/mueller/) pursues on one hand integrative structural biology and biochemical characterization of yeast and human Pol I and Pol III transcription complexes and their interaction with cellular factors in vitro to understand better their roles in human diseases including cancer. On the other hand, we explore in situ the role of Pol I and Pol III transcription in shaping the nucleolus and in genome organization using cryo-electron tomography, fluorescence microscopy and correlative approaches.

We are seeking highly motivated computational biologists to join the research group of Peer Bork within the Structural and Computational Biology Unit as a postdoctoral fellow. This bioinformatics group works on a wide range of topics with a current focus on microbiome analysis in ecosystems like the human gut and the ocean. Within the TREC (Traversing European Coastlines) project, we are gathering microbiome data from soil and ocean samples.