22 Postdoctoral Fellowship at Karolinska Institute, Sweden

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a Swedish doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We search for a postdoctoral researcher to work in the area of phage biology and phage engineering with a focus on augmentation of phage efficacy using genetic engineering.

As a member of the Fossati lab, you will apply and develop novel genetic screenings (based on CRISPRi) to characterize phage genes influencing clinical efficacy against bacterial pathogens, characterize them in their molecular context using interaction proteomics (affinity purification, proximity labelling, co-fractionation mass spectrometry, etc) and engineer ‘super-phages’ displaying increase efficacy against clinical isolates.  As a postdoctoral researcher, you will assume a prominent role in project design and management, oversee data generation, conduct analyses, and provide insightful interpretations. Collaboration with fellow team members, other groups at KI/SciLifeLab will be a key aspect of your role. You will be responsible for disseminating scientific findings through the authorship of research papers, active participation in scientific conferences, and effective communication with colleagues. Adaptability to a diverse, interdisciplinary, and global research environment, along with a commitment to ongoing professional growth, is essential.

We are looking for two highly motivated candidates with a PhD degree in cell or molecular biology, immunology, toxicology, or related subjects. Experience with the following techniques is required: primary cell cultures and transformed cell lines, confocal and light microscopy, flow cytometry, and other standard cell and molecular biology techniques. Furthermore, previous experience of single-cell analysis techniques, e.g., single-cell RNA sequencing and single-cell mass cytometry, is considered an advantage, as is previous experience of working with nanomaterials. Excellent communication skills (both spoken and written English) and the ability and willingness to interact with other members of the team are essential requirements. The post doc researchers will also support the principal investigator with project reporting, and attend projects meetings, in the frame of the EIC-funded projects.

We are seeking a postdoctoral fellow who will work on an exciting collaborative initiative aimed at novel biomarkers for perinatal depression and premenstrual disorders using large-scale multi-omics data. The project is part of a recently awarded prestigious European Research Council Starting Grant and applications are now invited for a postdoctoral position in Lu Lab (Institute of Environmental Medicine (IMM) at the Karolinska Institutet Solna campus.

We are looking for an outstanding, enthusiastic postdoc with strong analytical and laboratory skills who is working at the intersection of cancer and hematology. The aim is to generate novel knowledge about MDS biology, explore the antigen profile upon stem cell mutation and associate these findings with emerging anti-cancer therapies, particularly towards targeted immunotherapies. The postdoc candidate is also expected to be instrumental in the elaboration of hypotheses and designs to facilitate the translation of the work into new clinical initiatives.

The applicant will work in close collaboration with PhD students, postdocs, and researchers. The applicant is expected to investigate tumor-associated B cells and antibodies in clinical samples, and present results to general and specialized audiences. The applicant is expected to be highly engaged, curious, and a team player.

This call is part of the KI-SciLifeLab Clinical Translational Postdoc Program with the purpose of promoting interaction between the SciLifeLab research environment and clinical research environment at Karolinska Institutet. The postdocs that are recruited to the program will form a network with the support of the SciLifeLab Committee KI.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a Swedish doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are seeking a motivated and dedicated Postdoc to work on a collaborative project to develop, characterize and screen highly miniaturized liver models. The focus will be on functional drug testing, phenotypic profiling and image analysis. The applicant will be expected to regularly present and communicate the scientific results achieved both in a written and oral format, develop current protocols for handling primary human liver cells and interact with the larger project team from other academic institutions and industry.

We are looking for a highly motivated, driven, enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidate should have a strong collaborative approach to research, be a team player as well as capable of performing independently and contribute to a good social environment in the laboratory. The candidate must have a PhD in medical sciences, biochemistry, molecular biology or equivalent.

We are looking for a highly motivated postdoc with a strong bioinformatics background and a keen interest in using single-cell tools to understand the complexity of cell types, their potential interactions, and biological impacts within whole tissue. The successful candidate will employ single-cell technologies, including Smartseq3xpress, 10X, spatial transcriptomics, and chromatin accessibility sequencing (ATAC-seq and multi-omics), to profile the molecular identity, crosstalk, and cellular behavior along the auditory pathway under various conditions and across different species. The candidate is also expected to collaborate with international partners to integrate single-cell data with large GWAS studies. The overall aim is to provide a comprehensive understanding of the homeostatic cellular shifts in the auditory pathways underlying pathological hearing conditions.

We are looking for an ambitious postdoctoral researcher with a background in molecular biology and/or clinical cancer/leukemia research, to apply cutting edge epigenomic profiling techniques on liquid biopsy material. Plasma epigenomics is an exciting frontier in precision medicine, offering new means of diagnosing and monitoring human diseases by analyzing cell-free DNA and chromatin fragments circulating in the bloodstream. We offer an engaging and international research environment where you will contribute to high-quality research on an internationally competitive level.

The position is for a full-time employment, for two years. Part-time employment, e.g. in combination with clinical work, is a possibility.

We are seeking 1-2 postdoctoral fellows who will work on an exciting collaborative initiative aimed at investigating the behavioral language, physiological correlates, and molecular mechanisms responsible for the rapid-acting and long-term effects of various psychedelic compounds. The project is part of a recently awarded Karolinska Institutet Research Incubator (KIRI) project and applications are now invited for a co-supervised postdoctoral position in the Lopez (Department of Neuroscience, NEURO) and Lundberg (Department of Clinical Neuroscience, CNS) laboratories at Karolinska Institutet, Solna campus.

The postdoctoral researcher will be part of a joint collaboration between the Neurobiology of Stress and Treatment Response Research Group at NEURO led by Assistant Professor Juan Pablo Lopez and the Molecular Brain Imaging, Neuropsychopharmacology, Depression and Anxiety Disorders Research Group at CNS led by Adjunct Professor Johan Lundberg. Dr. Lopez leads a pre-clinical research program that studies the molecular mechanisms, cellular circuits, and behavioral correlates, associated with stress-related psychiatric disorders and their treatments, using animal models. The Lopez laboratory has significant expertise in a wide range of techniques, such as bulk and single-cell transcriptomics, viral-mediated gene manipulations, mouse models of stress/anxiety, using males and females, and automated behavioral tracking systems. Dr. Lundberg leads a clinical research program that aims to understand the pathophysiology and pharmacology of mood and anxiety disorders with the overarching goal to develop relevant biological markers for antidepressant treatment response. To this end, the Lundberg laboratory studies in vivo the molecular effects of different antidepressant treatments in humans. Dr. Lundberg has significant experience with various in vivo imaging techniques, such as PET, MEG and fMRI. Both supervisors are Core Members of the ECNP: Psychedelic research task working group, which will provide the postdoc with access to collaborations with internationally recognized European researchers and centers with a track-record within psychedelic research (both preclinical and clinical).

We are looking for a committed, well-established scientist working in the field of dementia risk reduction, with a special focus on multidomain interventions, to support and grow the NBN activites.

The project aims to tackle the rules of antigen recognition by γδT cells. Of the three classes of lymphocytes that constitute the adaptive immune system of jawed vertebrates, γδT cells are the only class for which principles of antigen recognition remain enigmatic and the nature of the antigens is largely elusive. Screens performed by the Kreslavsky lab have recently identified several novel unexpected γδT cell receptor (γδTCR) ligands (see link for further details). In this project, we will combine immunological expertise of the Kreslavsky lab with the structural biology expertise of the Rorbach lab to solve structures of γδTCRs with their unusual ligands. This in turn will shed light on the rules of antigen recognition of these mysterious cells, and through that – on their functions in immune responses against pathogens and cancer cells.

Enthusiastic and motivated applicants should have a strong background in structural biology and molecular biology. Previous immunology experience is desirable but not required.

The successful applicant should be knowledgeable of biological advancements, demonstrate a promising publication record, and have a rigorous scientific approach. 

Good documentation skills as well as proficiency in both spoken and written English are required. 

The successful candidates should be willing to work in a highly collaborative environment and to pursue his/her own independent research. Our research group is located in the world-leading Karolinska Institutet and works with groups within Sweden and abroad.  

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a Swedish doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The main task for a postdoctoral researcher in our research group is to produce scientific articles for publication in appropriate journals and other recognized media including all steps from study design, experimentation, data and statistical analysis, and scientific writing. Thus, is expected to play a leading role in group’s daily activities, such as processing routine samples, to develop new projects as well as to be a part in ongoing projects within group’s research areas. You will work in a diverse team and perform experimental work within a research laboratory environment. Flow cytometry as well as various cell and molecular biology methods and techniques are used to analyze patient material in our studies. Processing patient samples (blood or tissues), performing analyses, such as FACS, ELISA or PCR, are routine parts of the job in different projects. The applicant is also expected to supervise and train graduate and undergraduate students in the laboratory, present research and results at international conferences, and participate in writing grant applications. Performing administrative duties is also part of the job.

We are looking for a highly motivated, initiative-taking, technically skilled person that is passionate about pursuing translational research in T cell immunology. The successful candidate must have a critical mind, a collaborative, team-oriented and collegial attitude, and the inter-personal skills to effectively communicate and collaborate with colleagues of different backgrouds. Perseverance in working towards goals, excellent planning skills that allow for a high degree of flexibility when clinical samples arrive and a proactive and problem-solving attitude is required. The position furthermore requires dedication to the project, accuracy and attention to detail. The postdoc is required to be able to work both independently and as a collaborative and helpful team member. The position requires maintenance of accurate and detailed experimental records. The applicant should be scientifically curious, have a personality that fits in the groups, and an internal drive to promote a collaborative atmosphere within the group.  

Physical exercise and dietary improvements are key non-pharmacological strategies for metabolic syndrome and diabetes. These lifestyle changes reduce chronic oxidative stress and increase nitric oxide (NO) bioavailability. Our research focuses on inorganic nitrate, found in green leafy vegetables and beetroot, which converts to bioactive NO. Studies show nitrate improves cardiovascular function, reducing blood pressure, improving vascular function, and enhancing exercise parameters like mitochondrial efficiency and oxygen utilization. We hypothesize that dietary inorganic nitrate combined with physical exercise will provide significant cardiovascular protection for T2D patients, who are at high risk for CVD. This clinical trial will study the combined effects of structured physical exercise and dietary nitrate supplementation on cardiovascular health in T2D patients.

The Integrative Physiology research group at the Department of Molecular Medicine and Surgery at Karolinska Institutet is seeking a highly motivated postdoctoral researcher to join the group of Professor Juleen R. Zierath. The research in the group is focused on translational studies on cellular and molecular mechanisms underlying insulin resistance and type 2 diabetes and the effects of physical activity on glucose and lipid metabolism in skeletal muscle.

This project is designed to test the role of signal transducers to improve glucose homeostasis by targeting skeletal muscle glucose transport. The candidate will explore the molecular signal transducers involved in the regulation of glucose transport to restore glucose uptake in skeletal muscle from people with type 2 diabetes. The team has identified several candidates that may play a direct role in glucose transport. The postdoctoral fellow will validate the role of novel signal transducers in the regulation of glucose transport and insulin sensitivity using knock-down and over-expression approaches in primary human skeletal muscle cells. Promising candidates will be further validated in in vivo models of type 2 diabetes through electroporation approaches.

The postdoctoral fellow will determine how disease-relevant long non-coding RNAs (lncRNAs) regulate adipocyte insulin sensitivity and in turn metabolic health. This will be achieved by investigating human white adipose tissue (WAT) biopsies taken before and after systemic insulin infusion and couple these findings with state-of-the-art cellular models and in-house developed molecular approaches. This project aims to understand how lncRNAs contribute to the insulin response in adipocytes and discover novel targets that can be approached therapeutically. Full details are given here http://ki.se/en/srp-diabetes/postdoctoral-fellowships

Increased white adipose tissue mass is linked to type 2 diabetes, which in turn can be treated with several different anti-hyperglycemic drugs. However, there are large interindividual variations in the efficacy and side-effects of these interventions. We hypothesize that distinct adipocyte subtypes determine insulin sensitivity and outcomes following interventions with anti-hyperglycemic drugs. This project will test our model by spatially resolving treatment responses in human WAT based on samples from a clinical trial called DIASPAX (NCT05501483). In the study, we obtain adipose tissue biopsies, which we will use to generate single-nucleus RNA sequencing and spatial transcriptomic data. By jointly analyzing these data together with functional assessment of the tissue and assessments of clinical phenotypes, we will for the first-time link white adipose tissue heterogeneity to treatment responses. We are now looking for an ambitious postdoctoral fellow that will perform single-nucleus RNA sequencing and spatial transcriptomic analyses. The work will be undertaken in collaboration with other experts within the group as well as with members of the lab of Patrik Ståhl at SciLifeLab. There will be possibilities to follow-up key findings with wet lab experiments using state-of-the-art methods.

We are focused on understanding the crosstalk between tumor cells and the tumor microenvironment, and how these interactions initiate and drive tumor development. Our goal is to identify vulnerabilities that can be targeted for precision cancer medicine approaches. The postdoctoral candidate will lead a project aimed at identifying the early genetic and epigenetic events that contribute to tumor initiation and progression. Additionally, the candidate will play a key role in the lab’s drug discovery program.

Research in our lab integrates a variety of approaches, making us open to individuals from diverse backgrounds. A foundation in quantitative fields (e.g., mathematics, engineering, computer science, physics) and experience in theoretical neuroscience or experimental techniques (e.g., high-channel density silicon probe electrophysiology in vivo or in vitro, advanced animal behavior designs and analysis, miniscope or two-photon imaging) is advantageous. Candidates are expected to demonstrate previous productivity, often by publications, but not exclusively.