MPV Blood Test: Calculation, High and Low MPV Value, Results

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What is MPV in Blood Test?

The MPV (Mean Platelet Volume) test is used to assess the average size of platelets in a blood sample.

Platelets are vital blood cells that are in charge of blood clotting, a process which regulates blood loss after an injury.
The mean platelet volume (MPV) is a measurement of platelet dimension derived by haematological analyzers based on the volume dispersion throughout a routine blood morphology test.
The MPV blood testing is conducted as part of the Complete Blood Count (CBC), which is a thorough blood analysis test.
The MPV test is critical since the average size of platelets increases when the body produces a significant number of platelets, allowing for conclusions about platelet creation as well as destruction.
The MPV test is not used to diagnose specific disorders; rather, it is used as part of a comprehensive body check-up procedure.
The test is similar to the platelet count test, which determines the maximum count of platelets in a blood sample.
The outcomes of MPV testing may not be significant on its own, but they should only be interpreted in the context of other CBC tests.
The normal MPV varies between 7.5 and 12 fl (femtolitre), with big platelets accounting for 0.2-5.0 percent of the total platelet population.

MPV levels are evaluated as part of the CBC, which is a blood analysis procedure.
MPV values are obtained by dividing the total mass of platelets in a blood sample (plateletcrit) by the total number of platelets in the blood sample.
In physiological situations, MPV is inversely proportional to platelet count, which is connected with homeostasis as well as the preservation of steady platelet mass.

In humans, the average or normal value of MPV remains between 7.5 to 12 fl.
Abnormally high or low readings may suggest the presence of various diseases or abnormalities in the individual’s body.
Further study may be necessary in the case of results with greater or lower MPV values.
Abnormal results are not often regarded indicators of serious health problems; but, in some situations, they might be significant, thus they must be ruled out.
Based on the inverse link between MPV as well as total platelet count, a decrease in their mean volume is accompanied by an increase in platelet production.
The physiological proportion between MPV as well as platelet count is altered in a variety of pathological situations, which aids in the identification of certain of these pathological disorders.
A low or high MPV value may be totally normal depending on an individual’s lifestyle. As a result, an interpretation should be made only when all of the CBC tests have been completed.

When an MPV value exceeds 12 fl, it is considered higher than normal. This shows that the platelets’ average size is greater than the average.
However, the MPV test result cannot be understood in isolation. The entire platelet count should be included.
If the MPV number is high but the total platelet count is low, it indicates that the bone marrow is manufacturing platelets quickly.
Platelets which are new or young are larger and have recently been released from the bone marrow, whereas older platelets are smaller and circulate through the bloodstream.
A higher MPV number may also indicate that older platelets are being destroyed, causing new platelets to be generated in the bone marrow.
Because a rise in MPV correlates with platelet activation, it is probable that it is a cause of some forms of cancer which result in platelet activation.
Furthermore, a higher MPV number may be symptomatic of various conditions such as heart disease, hypothyroidism, stroke, or high blood pressure.

A low MPV value is defined as one which is less than 7.5 fl. This means that the average size of the platelets is less than normal.
Since older platelets are smaller, a low MPV number may suggest that the bone marrow is not creating enough platelets.
However, the low value of an MPV on its own is meaningless. As a result, it should always be accompanied by a total platelet count.
In some circumstances, low MPV values are reported in chemotherapy patients because they are injected with cytotoxic drugs which produce a drop in platelet count.
Furthermore, other disorders such as inflammatory bowel disease and aplastic anaemia could be the cause of this.

MPV Blood Test Citations

https://www.hindawi.com/journals/mi/2019/9213074/
https://www.healthline.com/health/mpv-test
http://ddxhub.com/1_2_10_mean.htm
https://www.researchgate.net/publication/221891888_Are_platelet_indices_of_clinical_use_A_multidisciplinary_review
https://www.flashcardmachine.com/values.html
https://www.emedicinehealth.com/complete_blood_count_cbc/article_em.htm
https://www.answers.com/Q/Which_type_of_blood_cell_helps_in_the_clotting_of_blood
https://medlineplus.gov/lab-tests/mpv-blood-test/
https://en.islcollective.com/english-esl-worksheets/search/Diagnostic+Test
http://njmr.in/uploads/3-2_162-165.pdf
http://diseaseslist.org/mpv-blood-test-high-low-normal/